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1

Screening of β-2 agonists and confirmation of fenoterol, orciprenaline, reproterol and terbutaline with gas chromatography–mass spectrometry as tetrahydroisoquinoline derivatives

Maria Kristina Henze, Georg Opfermann, Hildegard Spahn-Langguth, Wilhelm Schänzer

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

2001

Language:

english

File:

PDF, 285 KB

english, 2001

2

Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds — implications for pharmacokinetics of selected substrates

Amal Abou El Ela, Sebastian Härtter, Ulrich Schmitt, Christoph Hiemke, Hildegard Spahn-Langguth, Peter Langguth

Journal:

Journal of Pharmacy and Pharmacology

Year:

2004

Language:

english

File:

PDF, 165 KB

english, 2004

3

Grapefruit juice enhances intestinal absorption of the P-glycoprotein substrate talinolol

H Spahn-Langguth, P Langguth

Journal:

European Journal of Pharmaceutical Sciences

Year:

2001

Language:

english

File:

PDF, 89 KB

english, 2001

4

Nanosuspension Formulations for Low-Soluble Drugs: Pharmacokinetic Evaluation Using Spironolactone as Model Compound

Langguth, P., Hanafy, A., Frenzel, D., Grenier, P., Nhamias, A., Ohlig, T., Vergnault, G., Spahn-Langguth, H.

Journal:

Drug Development and Industrial Pharmacy

Year:

2005

Language:

english

File:

PDF, 515 KB

english, 2005

5

Needed: a new US civilian space strategy

Hanses, A., Spahn-Langguth, H., Meiss, F., Mutschler, E.

Journal:

Year:

1986

Language:

english

File:

PDF, 107 KB

english, 1986

6

TALC PNEUMOCONIOSIS

Hanses, A., Spahn-Langguth, H., Meiss, F., Mutschler, E.

Journal:

Year:

1951

Language:

english

File:

PDF, 189 KB

english, 1951

7

Caco-2 versus caco-2/HT29-MTX co-cultured cell lines: Permeabilities via diffusion, inside- and outside-directed carrier-mediated transport

Constanze Hilgendorf, Hildegard Spahn-Langguth, Carl G. Regårdh, Elke Lipka, Gordon L. Amidon, Peter Langguth

Journal:

Journal of Pharmaceutical Sciences

Year:

2000

Language:

english

File:

PDF, 491 KB

english, 2000

8

Rapid Assay for the Quantification of Piretanide in Biological Fluids

Hildegard Spahn-Langguth, Gabriele Hahn, Ernst Mutschler

Journal:

Archiv der Pharmazie

Year:

1991

Language:

english

File:

PDF, 250 KB

english, 1991

9

Saturable Enantioselective First-pass Effect for Carvedilol after High Oral Racemate Doses in Rats

E. Stahl, D. Henke, E. Mutschler, H. Spahn-Langguth

Journal:

Archiv der Pharmazie

Year:

1993

Language:

english

File:

PDF, 276 KB

english, 1993

10

Carvedilol Stereopharmacokinetics in Rats: Affinities to Blood Constituents and Tissues

Elke Stahl, Ernst Mutschler, Ulrich Baumgartner, Hildegard Spahn-Langguth

Journal:

Archiv der Pharmazie

Year:

1993

File:

PDF, 457 KB

1993

11

Simultaneous Determination of (R)- and (S)-Brefanolol in Human Plasma: High-Performance Liquid Chromatographic Assay on a Chiral Stationary Phase

Monika Neubeckm, Dorit Henke, Hildegard Spahn-Langguth, Ernst Mutschler

Journal:

Archiv der Pharmazie

Year:

1994

Language:

english

File:

PDF, 287 KB

english, 1994

12

A New Rapid and Sensitive High-Performance Liquid Chromatographic Assay for Diclofenac in Human Plasma

Antje Hanses, Hildegard Spahn-Langguth, Ernst Mutschler

Journal:

Archiv der Pharmazie

Year:

1995

Language:

english

File:

PDF, 374 KB

english, 1995

13

Variable gastric emptying and discontinuities in drug absorption profiles: Dependence of rates and extent of cimetidine absorption on motility phase and pH

Peter Langguth, Kathleen M. Lee, Hildegard Spahn-Langguth, Dr Gordon L. Amidon

Journal:

Biopharmaceutics & Drug Disposition

Year:

1994

Language:

english

File:

PDF, 1.29 MB

english, 1994

14

Influence of green and black tea on folic acid pharmacokinetics in healthy volunteers: potential risk of diminished folic acid bioavailability

N. Ceren Alemdaroglu, Ulrich Dietz, Siegfried Wolffram, Hildegard Spahn-Langguth, Peter Langguth

Journal:

Biopharmaceutics & Drug Disposition

Year:

2008

Language:

english

File:

PDF, 239 KB

english, 2008

15

ChemInform Abstract: Dimeric 4-Aryl-1,4-dihydropyridines as Novel HIV-1 Protease Inhibitors — Affinities to Intestinal P-Glycoprotein.

A. Hilgeroth, C. Dressler, S. Neuhoff, H. Spahn-Langguth, P. Langguth

Journal:

Year:

2001

File:

PDF, 31 KB

2001

16

Pharmacokinetic studies with the lipid-regulating agent beclobrate: Enantiospecific assay for beclobric acid using a new fluorescent chiral coupling component (S-FLOPA)

Sascha Mayer, Ernst Mutschler, Dr. Hildegard Spahn-Langguth

Journal:

Year:

1991

Language:

english

File:

PDF, 685 KB

english, 1991

17

Rats with portacaval shunt as a potential experimental pharmacokinetic model for liver cirrhosis: Application to carvedilol stereopharmacokinetics

Elke Stahl, Ulrich Baumgartner, Dorit Henke, Jürgen Schölmerich, Ernst Mutschler, Dr. Hildegard Spahn-Langguth

Journal:

Year:

1993

Language:

english

File:

PDF, 791 KB

english, 1993

18

In vitro and in vivo irreversible plasma protein binding of beclobric acid enantiomers

Sascha Mayer, Ernst Mutschler, Dr. Hildegard Spahn-Langguth, Leslie Z. Benet

Journal:

Year:

1993

Language:

english

File:

PDF, 585 KB

english, 1993

19

Chloroformates and isothiocyanates derived from 2-arylpropionic acids as chiral reagents: synthetic routes and chromatographic behaviour of the derivatives

Ralf Büschges, Hermann Linde, Ernst Mutschler, Hildegard Spahn-Langguth

Journal:

Journal of Chromatography A

Year:

1996

Language:

english

File:

PDF, 837 KB

english, 1996

20

Determination of the quaternary compound ciclotropium in human biological material after hydrolysis and derivatization with the fluorophor flunoxaprofen chloride

Bettina Liebmann, Dorit Henke, Hildegard Spahn-Langguth, Ernst Mutschler

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1991

Language:

english

File:

PDF, 971 KB

english, 1991

21

Enantiospecific high-performance liquid chromatographic assay with fluorescence detection for the monoamine oxidase inhibitor tranylcypromine and its applicability in pharmacokinetic studies

Hildegard Spahn-Langguth, Gabriele Hahn, Ernst Mutschler, Werner Möhrke, Peter Langguth

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1992

Language:

english

File:

PDF, 536 KB

english, 1992

22

New specific and sensitive HPLC-assays for ethacrynic acid and its main metabolite — the cysteine conjugate — in biological material

Barbara Voith, Hildegard Spahn-Langguth, Ernst Mutschler

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Year:

1995

Language:

english

File:

PDF, 612 KB

english, 1995

23

4-(6-Methoxy-2-naphthyl)-2-butyl chloroformate enantiomers: New reagents for the enantiospecific analysis of amino compounds in biogenic matrices

R. Büschges, R. Devant, E. Mutschler, H. Spahn-Langguth

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Year:

1996

Language:

english

File:

PDF, 1.39 MB

english, 1996

24

The influence of age on the pharmacokinetics and pharmacodynamics of bemetizide and triamterene: a single and multiple dose study

W Mühlberg, E Mutschler, A Hofner, H Spahn-Langguth, O Arnold

Journal:

Archives of Gerontology and Geriatrics

Year:

2001

Language:

english

File:

PDF, 147 KB

english, 2001

25

HPLC assays to simultaneously determine the angiotensin-AT1 antagonist losartan as well as its main and active metabolite EXP 3174 in biological material of humans and rats

Andrea Soldner, Hildegard Spahn-Langguth, Ernst Mutschler

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Year:

1998

Language:

english

File:

PDF, 161 KB

english, 1998

26

A radioreceptor assay for the analysis of AT1-receptor antagonists: Correlation with complementary LC data reveals a potential contribution of active metabolites

Andrea Soldner, Hildegard Spahn-Langguth, Dieter Palm, Ernst Mutschler

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Year:

1998

Language:

english

File:

PDF, 218 KB

english, 1998

27

Determination of triamterene and its main metabolite hydroxytriamterene sulfate in human urine by capillary electrophoresis using ultraviolet absorbance and laser-induced fluorescence detection

Christian Horstkötter, Susan Kober, Hildegard Spahn-Langguth, Ernst Mutschler, Gottfried Blaschke

Journal:

Journal of Chromatography B

Year:

2002

Language:

english

File:

PDF, 350 KB

english, 2002

28

Active metabolites formed during hepatic first-pass: simulations featuring their contribution to the overall effect in altered liver clearance and drug-drug interactions

Ahmed M Abdelaziz, Mohammad al-Araby, Laila Mahran, Hilde Spahn-Langguth

Journal:

BMC Pharmacology

Year:

2009

Language:

english

File:

PDF, 105 KB

english, 2009

29

The effect of ciclotropium on human heart rate

R. W. Ding, R. E. Port, K. Ortmann, B. Liebmann, H. Spahn-Langguth, E. Mutschler, E. Weber

Journal:

European Journal of Clinical Pharmacology

Year:

1994

Language:

english

File:

PDF, 404 KB

english, 1994

30

Comparative enantioselective pharmacokinetic studies of celiprolol in healthy volunteers and patients with impaired renal function

C. Hartmann, M. Frölich, D. Krauß, H. Spahn-Langguth, H. Knauf, E. Mutschler

Journal:

European Journal of Clinical Pharmacology

Year:

1990

Language:

english

File:

PDF, 359 KB

english, 1990

31

In SilicoModeling of Non-Linear Drug Absorption for the P-gp Substrate Talinolol and of Consequences for the Resulting Pharmacodynamic Effect

Marija Tubic, Daniel Wagner, Hilde Spahn-Langguth, Michael B. Bolger, Peter Langguth

Journal:

Pharmaceutical Research

Year:

2006

Language:

english

File:

PDF, 446 KB

english, 2006

32

Concentration-Dependent Effect of Naringin on Intestinal Absorption of β1-Adrenoceptor Antagonist Talinolol Mediated by P-Glycoprotein and Organic Anion Transporting Polypeptide (Oatp)

Yoshiyuki Shirasaka, Yan Li, Yuta Shibue, Erika Kuraoka, Hildegard Spahn-Langguth, Yukio Kato, Peter Langguth, Ikumi Tamai

Journal:

Pharmaceutical Research

Year:

2009

Language:

english

File:

PDF, 177 KB

english, 2009

33

Gemfibrozil and its oxidative metabolites: quantification of aglycones, acyl glucuronides, and covalent adducts in samples from preclinical and clinical kinetic studies

Andreas Hermening, Ann-Katrin Gräfe, Gül Baktir, Ernst Mutschler, Hildegard Spahn-Langguth

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

2000

Language:

english

File:

PDF, 245 KB

english, 2000

34

P-glycoprotein (P-gp) mediated efflux in Caco-2 cell monolayers: The influence of culturing conditions and drug exposure on P-gp expression levels

Pascale Anderle, Eva Niederer, Werner Rubas, Constanze Hilgendorf, Hilde Spahn-Langguth, Heidi Wunderli-Allenspach, Hans P. Merkle, Peter Langguth

Journal:

Journal of Pharmaceutical Sciences

Year:

1998

Language:

english

File:

PDF, 109 KB

english, 1998

35

Role of P-glycoprotein-mediated secretion in absorptive drug permeabiity: An approach using passive membrane permeability and affinity to P-glycoprotein

Stephan Doppenschmitt, Hildegard Spahn-Langguth, Carl Gunnar Regårdh, Peter Langguth

Journal:

Journal of Pharmaceutical Sciences

Year:

1999

Language:

english

File:

PDF, 126 KB

english, 1999

36

Enhanced covalent binding of tolmetin to proteins in humans after multiple dosing

Zia-Amirhosseini, Parnian, Ojingwa, Joseph C, Spahn-Langguth, Hildegard, McDonagh, Antony F, Benet, Leslie Z

Journal:

Clinical Pharmacology & Therapeutics

Year:

1994

Language:

english

File:

PDF, 321 KB

english, 1994

37

Evidence for Intestinal Secretion as an Additional Clearance Pathway of Talinolol Enantiomers: Concentration- and Dose-dependent Absorption in Vitro and in Vivo

Ulrike Wetterich, Hildegard Spahn-Langguth, Ernst Mutschler, Bernd Terhaag, Wolfgang Rösch, Peter Langguth

Journal:

Pharmaceutical Research

Year:

1996

File:

PDF, 1.59 MB

1996

38

Comparative Pharmacodynamics and Pharmacokinetics of Candesartan and Losartan in Man

BETTINA FUCHS, KERSTIN BREITHAUPT-GRÖGLER, GUSTAV G. BELZ, SUSANNA ROLL, CLAUDIUS MALERCZYK, VOLKER HERRMANN, HILDEGARD SPAHN-LANGGUTH, ERNST MUTSCHLER

Journal:

Journal of Pharmacy and Pharmacology

Year:

2000

Language:

english

File:

PDF, 133 KB

english, 2000

39

Reversible binding of tolmetin, zomepirac, and their glucuronide conjugates to human serum albumin and plasma

Joseph C. Ojingwa, Hildegard Spahn-Langguth, Leslie Z. Benet

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

1994

Language:

english

File:

PDF, 1.22 MB

english, 1994

40

Celiprolol double-peak occurrence and gastric motility: Nonlinear mixed effects modeling of bioavailability data obtained in dogs

Elke Lipka, I-Der Lee, Peter Langguth, Hildegard Spahn-Langguth, Ernst Mutschler, Gordon L. Amidon

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

1995

Language:

english

File:

PDF, 944 KB

english, 1995

41

Computer-Assisted HPLC Method Development for Determination of Tolmetin and Possible Kinetic Modulators of Its Oxidative Metabolism in Vivo

Rasha Hanafi, Hilde Spahn-Langguth, Laila Mahran, Ola Heikal, Abeer Hanafy, Hans Rieger, Imre Molnár, Hassan Y. Aboul-Enein

Journal:

Chromatographia

Year:

2012

Language:

english

File:

PDF, 393 KB

english, 2012

42

Erratum to: Computer-Assisted HPLC Method Development for Determination of Tolmetin and Possible Kinetic Modulators of Its Oxidative Metabolism in Vivo

Hanafi, Rasha, Spahn-Langguth, Hilde, Mahran, Laila, Heikal, Ola, Hanafy, Abeer, Rieger, Hans, Molnár, Imre, Aboul-Enein, Hassan Y.

Journal:

Chromatographia

Year:

2012

Language:

english

File:

PDF, 94 KB

english, 2012

43

Pharmacokinetic evaluation of oral fenofibrate nanosuspensions and SLN in comparison to conventional suspensions of micronized drug

A. Hanafy, H. Spahn-Langguth, G. Vergnault, P. Grenier, M. Tubic Grozdanis, T. Lenhardt, P. Langguth

Journal:

Advanced Drug Delivery Reviews

Year:

2007

Language:

english

File:

PDF, 615 KB

english, 2007

44

Modulation of drug transport by selected flavonoids: Involvement of P-gp and OCT?

Monika Ofer, Siegfried Wolffram, Annette Koggel, Hilde Spahn-Langguth, Peter Langguth

Journal:

European Journal of Pharmaceutical Sciences

Year:

2005

Language:

english

File:

PDF, 156 KB

english, 2005

45

Effects of controlled-release on the pharmacokinetics and absorption characteristics of a compound undergoing intestinal efflux in humans

Marija Tubic, Daniel Wagner, Hildegard Spahn-Langguth, Christine Weiler, Roland Wanitschke, Wulf Otto Böcher, Peter Langguth

Journal:

European Journal of Pharmaceutical Sciences

Year:

2006

Language:

english

File:

PDF, 529 KB

english, 2006

46

Bidirectional membrane transport: Simulations of transport inhibition in uptake studies explain data obtained with flavonoids

Monika Ofer, Peter Langguth, Hilde Spahn-Langguth

Journal:

European Journal of Pharmaceutical Sciences

Year:

2006

Language:

english

File:

PDF, 553 KB

english, 2006

47

Baclofen ester and carbamate prodrug candidates: A simultaneous chromatographic assay, resolution optimized with DryLab®

Rasha Hanafi, Salwa Mosad, Khaled Abouzid, Raimund Nieß, Hilde Spahn-Langguth

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Year:

2011

Language:

english

File:

PDF, 736 KB

english, 2011

48

Intestinal drug efflux: formulation and food effects

D. Wagner, H. Spahn-Langguth, A. Hanafy, A. Koggel, P. Langguth

Journal:

Advanced Drug Delivery Reviews

Year:

2001

Language:

english

File:

PDF, 694 KB

english, 2001

49

Pretreatment with potent P-glycoprotein ligands may increase intestinal secretion in rats

Abeer Hanafy, Peter Langguth, Hildegard Spahn-Langguth

Journal:

European Journal of Pharmaceutical Sciences

Year:

2001

Language:

english

File:

PDF, 279 KB

english, 2001

50

In vivo non-linear intestinal permeability of celiprolol and propranolol in conscious dogs: evidence for intestinal secretion

E. Lipka, H. Spahn-Langguth, E. Mutschler, G.L. Amidon

Journal:

European Journal of Pharmaceutical Sciences

Year:

1998

Language:

english

File:

PDF, 767 KB

english, 1998

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